Listen 8225

<VirtualHost *:8225>
    ServerName destinataire.example
    DocumentRoot /var/www/roundcubemail/public_html/

    <Directory />
        Options FollowSymLinks
        AllowOverride All
    </Directory>

    <Directory /var/www/roundcubemail>
        Options FollowSymLinks MultiViews
        AllowOverride All
        Require all granted
    </Directory>
</VirtualHost>